Rejuvenated Stem Cells

Centagen has developed an engineered system to rejuvenate your stem cells and reverse-age tissues and organs in healthy humans of any age.  Centagen’s system will reverse age a person’s cells by reprogramming adult stem cells into a fetal-like state called Rejuvenated Stem (RS) cells.  The RS cells are expanded in automated bioreactors to more than a billion multipotent RS cells without aging them. Injected RS cells can then rejuvenate multiple tissues and organs.

No genetic engineering of the RS cells takes place in cell reprogramming, so the procedure is much safer than the genetic tampering commonly done by many companies developing reprogrammed stem cell treatments. Also, only your own adult stem cells are used, so there are no ethical issues with embryonic stem cell use or medical side effects due to immunity to foreign stem cells. 

Regenerative Medicine 3.0

While rejuvenated stem (RS) cells are essential to rejuvenating old tissues and organs, potent stem cell function also depends critically on the support from its micro-environment in the body. Senescing cells accumulate with age to increase the circulating levels of pro-inflammatory cytokines and other local systemic toxins that inhibit RS cell function in older patients and can limit both long term survival and engraftment of RS cells injected into the body. 

To prepare the patient’s senescing organs and tissues for optimized RS cell engraftment, Centagen has designed small molecule botanical drugs that target at least 8 critical age-related pathways affecting stem cell growth, health, and lifespan (e.g. see pathway review in Hallmarks of Aging):

For example, Centagen has developed a 10-compound Stem Cell 100+ (SC100+) and a 17-compound Memex 100+, which are patent-pending multipath botanical drugs that target the critical 8 age-related pathways linked to the aging process[1-3].  SC100+ has proven effective for treating markers of aging or of age-related disorders[4, 5].  An earlier 8 compound version of Memex 100+(MX100) was shown to help with age-related brain conditions in both animal models [6] and in human clinical trials [3, 7].